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Exercise decrease the expression of MCP-1 in perivascular adipose tissue (PVAT) in obese mice

  • Hotimah Masdan Salim ,
  • Aisyah Aisyah ,
  • Michio Shimabukuro ,


Introduction: Exercise has been believed to prevent metabolic syndrome (Mets) from occurring.  Accumulation of inflammation factors such as monocytes chemoattractant protein-1 (MCP1) in adipose tissue is a factor in the development of MetS. However, the inflammatory mediators that play a role in the accumulation of macrophages are still unclear, so this study aims to determine the expression of MCP-1 in perivascular adipose tissue (PVAT).

Methods: Eight-week-old male wild-type mice, were divided into five groups. One control group was given a standard diet and four groups were given a high-fat diet (HFD) for 2 weeks. Exercise treatment was given to the HFD group by dividing HFD with exercise once a week, HFD with exercise three times a week, and HFD with exercise five times a week. As for the exercise, speed is given 10-18m/minute for 30 minutes. and this exercise is carried out for two weeks. Gene expression of MCP-1 in PVAT tissues was analyzed using quantitative chain reaction (PCR).

Results: The HFD group experienced an increase in body weight (P <0.01) and adipose tissue mass (P <0.01) compared to the control group. Furthermore, exercise decreased body weight (P <0.05) and adipose tissue in the HFD-Exc1 group (P <0.01). Furthermore, exercise tends to decrease the inflammatory mediator in macrophages MCP-1 in PVAT compared to the HFD group.

Conclusion: These results suggested that exercise partially reduces adiposity, tended to decreases MCP-1 in HFD-induced obesity.


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How to Cite

Salim, H. M. ., Aisyah, A., & Shimabukuro, M. (2022). Exercise decrease the expression of MCP-1 in perivascular adipose tissue (PVAT) in obese mice. Bali Medical Journal, 11(3), 1126–1129.




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Hotimah Masdan Salim
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Aisyah Aisyah
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Michio Shimabukuro
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