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The effect of demographic and clinical characteristics toward ocular surface squamous neoplasia (OSSN) recurrence after tumor excision surgery in Dr. Soetomo General Hospital, Indonesia: A literature review

  • Agung Bhakti Wiratama ,
  • Susy Fatmariyanti ,
  • Rozalina Loebis ,

Abstract

Link of Video Abstract: https://www.youtube.com/watch?v=M4wrqsa21hw

 

An essential component of the ocular surface is the conjunctiva. The most common non-pigmented malignancy that can affect the conjunctiva is ocular surface squamous neoplasia (OSSN). Despite the vast investigations on this deadly organism, certain elements related to demographics, clinical traits, and recurrence remain unclear. The objective of this review was to explore OSSN in depth. OSSN is classified into several types based on its clinical morphology, such as nodular, plaque, and diffuse OSSN. Plaque types can be classified into gelatinous, leucoplakia, and papilliform. Histopathological classification of OSSN consists of benign, pre-invasive, and invasive types. The OSSN tumor stadium can be classified using the TNM criteria by the American Joint Committee on Cancer (AJCC). OSSN management can be divided into medical and surgical management based on classification and tumor stadium. Despite the advances in the treatment of OSSN, there are still variances and conflicting results in the recurrence after surgery, which certain demographic and clinical types of OSSN might cause. Further study is needed to confirm the significance of the recurrence of each demographic and clinical characteristic of each OSSN tumor.

References

  1. Gichuhi S, Sagoo MS, Weiss HA, Burton MJ. Epidemiology of ocular surface squamous neoplasia in Africa. Trop Med Int Health. 2013 Dec;18(12):1424–43.
  2. Krishnaraj J, Das SS, Vendhan KE. Ocular surface squamous neoplasia (OSSN). 2016.
  3. Djelantik AAAS, Yuliawati P, Naryati LPE. Prevalence and risk factors of pterygium occurrence in population above 50 years old in Bali. Bali Med J.2016;5(3):528–32.
  4. Alvarez OP, Zein M, Galor A, Karp CL. Management of ocular surface squamous neoplasia: Bowman Club Lecture 2021. BMJ Open Ophthalmol. 2021;6.
  5. Gurnani B, Kaur K. Ocular Surface Squamous Neoplasia. In Treasure Island (FL); 2023.
  6. Karp CL, Mercado C, Venkateswaran N, Ruggeri M, Galor A, Garcia A, et al. Use of high-resolution optical coherence tomography in the surgical management of ocular surface squamous neoplasia: a pilot study. Am J Ophthalmol. 2019;206:17–31.
  7. Mittal RR, Rath S, Vemuganti GK. Ocular surface squamous neoplasia - Review of etio-pathogenesis and an update on clinico-pathological diagnosis. Saudi J Ophthalmol Off J Saudi Ophthalmol Soc. 2013;27 3:177–86.
  8. Asadi-Amoli F, Ghanadan A. Survey of 274 patients with conjunctival neoplastic lesions in Farabi Eye Hospital, Tehran 2006–2012. J Curr Ophthalmol. 2015;27:37–40.
  9. Dandala P, Malladi P, Kavitha. Ocular surface squamous neoplasia (OSSN): A retrospective study. J Clin Diagn Res. 2015;9 11:NC10-3.
  10. Ong SS, Vora GK, Gupta PK. Anterior segment imaging in ocular surface squamous neoplasia. J Ophthalmol. 2016;2016:5435092.
  11. Das S, Nagesh N, Hegde R. Ocular surface squamous neoplasia. Key Top Ophthalmol. 2019.
  12. Hӧllhumer R, Williams S, Michelow PM. Observational study of ocular surface squamous neoplasia: Risk factors, diagnosis, management and outcomes at a tertiary eye hospital in South Africa. PLoS One. 2020;15.
  13. Xu Z, Taylor JA. Genome-wide age-related DNA methylation changes in blood and other tissues relate to histone modification, expression and cancer. Carcinogenesis. 2014;35(2):356–64.
  14. Pfeifer GP. Mechanisms of UV-induced mutations and skin cancer. Genome Instab Dis. 2020;1(3):99–113.
  15. Id SW, Michelow P. Observational study of ocular surface squamous neoplasia : Risk factors , diagnosis , management and outcomes at a tertiary eye hospital in South Africa. 2020;1–12.
  16. Viswamithra P, Bhaskara N. Ocular surface squamous neoplasia. J Dr NTR Univ Heal Sci. 2014;3:185.
  17. Nanji AA, Mercado C, Galor A, Dubovy SR, Karp CL. Updates in ocular surface tumor diagnostics. Int Ophthalmol Clin. 2017;57(3):47-62.
  18. Nguena MB, van den Tweel JG, Makupa WU, Hu VH, Weiss HA, Gichuhi S, et al. Diagnosing ocular surface squamous neoplasia in East Africa. Ophthalmology. 2014;121:484–91.
  19. Gupta DR. Clinical profile of ocular surface squamous neoplasia (Ossn). Int J Med Biomed Stud. 2019;3(6):9–17.
  20. Xu Y, Zhou Z, Xu Y, Wang M, Liu F, Qu H, et al. The clinical value of in vivo confocal microscopy for diagnosis of ocular surface squamous neoplasia. Eye (Lond). 2012;26(6):781–7.
  21. Ma IH, Hu FR, Wang IJ, Chen WL, Hsu YJ, Chu HS, et al. Clinicopathologic correlation of ocular surface squamous neoplasia from a university hospital in North Taiwan 1994 to 2014. J Formos Med Assoc. 2019;118(4):776–82.
  22. Honavar SG, Manjandavida FP. Tumors of the ocular surface: A review. Indian J Ophthalmol. 2015;63:187–203.
  23. Cicinelli MV, Marchese A, Bandello F, Modorati G. Clinical management of ocular surface squamous neoplasia: a review of the current evidence. Ophthalmol Ther. 2018 Dec;7(2):247–62.
  24. Meel R, Dhiman R. Proposal for a new classification for ocular surface squamous neoplasia. Eye (Lond). 2018;32(7):1284-5.
  25. Gokharman D, Aydin S. Magnetic resonance imaging in orbital pathologies: a pictorial review. J Belg Soc Radiol. 2018;101(1):5.
  26. Jakobiec FA, Homer NA, Zakka FR, Curtin HD, Fay AM. Clinicopathologic and magnetic resonance imaging analysis of a multifocal orbital lymphoid tumor. Ocul Oncol Pathol. 2017;4:82–9.
  27. Nagesh CP, Rao R, Hiremath SB, Honavar SG. Magnetic resonance imaging of the orbit, Part 2: Characterization of orbital pathologies. Indian J Ophthalmol. 2021;69(10):2585–616.
  28. Alkatan HM, Al-Motlak MA, Al-Shedoukhy AA. Metastatic squamous spindle cell carcinoma of the conjunctiva. Saudi J Ophthalmol Off J Saudi Ophthalmol Soc. 2010;24(4):155–8.
  29. Li AS, Shih CY, Rosen L, Steiner A, Milman T, Udell IJ. Recurrence of ocular surface squamous neoplasia treated with excisional biopsy and cryotherapy. Am J Ophthalmol. 2015;160(2):213-219.e1.
  30. Al Bayyat G, Arreaza-Kaufman D, Venkateswaran N, Galor A, Karp CL. Update on pharmacotherapy for ocular surface squamous neoplasia. Eye Vis (London, England). 2019;6:24.
  31. Murthy RK, Gupta H, Krishnatry R, Laskar S. Electron beam radiotherapy for the management of recurrent extensive ocular surface squamous neoplasia with orbital extension. Indian J Ophthalmol. 2015;63:672–4.

How to Cite

Agung Bhakti Wiratama, Fatmariyanti, S. ., & Loebis, R. . (2023). The effect of demographic and clinical characteristics toward ocular surface squamous neoplasia (OSSN) recurrence after tumor excision surgery in Dr. Soetomo General Hospital, Indonesia: A literature review. Bali Medical Journal, 12(3), 2656–2667. https://doi.org/10.15562/bmj.v12i3.4693

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Agung Bhakti Wiratama
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Susy Fatmariyanti
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Rozalina Loebis
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